Endocrine Abstracts

Aim: To evaluate the effectiveness of the Bethesda system for reporting thyroid cytopathology in the prediction of thyroid cancer on fine needle aspiration (FNA).Materials and methods: This is retrospective study of 70 detected thyroid cancer. Thyroid ultrasound and FNA were performed on all patients. 66 of them with cancer suspicion were communicated to the thyroid surgeon, 4 cases of papillary carcinoma were accidentally diagnosed after hystological in...

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. The effect of therapy of acromegaly on pathogenesis of CMD is not clear.Aim: To assess the effect of somatostatin analogues (SSA) on pathogenesis of carbohydrate metabolism disturbance in acromegaly.Patients and methods: 103 acromegaly patients were examined (31 men, 72 women; age 54 (46–61) years; 60 had newly diagnosed acromegaly (NA)...

Objective: To evaluate the frequency of symptoms of Cushing’s disease (CD) at baseline and it dependence on different quantities.Material and methods: Clinical and laboratory data of 44 patients with CD (40 females and four males, 37.9±10.5 years old), duration of the disease 35.5 (22; 75) months.Results: Complaints: i) >80% – fatigability, weight gain, apathy, and headache, ii) 40–50% – loss of libido,...

For the purpose to compare sleep breathing disorders (SBD) in untreated and treated patients with acromegaly, we examined 55 patients with acromegaly (18 men and 37 women): 27 patients with newly diagnosed acromegaly, age 56.0 (47.0; 64.0) y.o., BMI 30.2 (27.8; 34.4) kg/m2, GH levels 12.8 (4.6; 23.0) ng/ml, IGF-1 245 (106; 331) % of upper normal limit (UNL), hypertension duration 6.5 (1.0; 14.8) years; 28 patients with treated acromegaly, age 57.0 (47.3; 64.8) y.o., BMI 30.7 ...

Aim: To estimate the frequency of changes in thyroid function on the background of antiviral therapy in patients with chronic hepatitis C.Material and methods: The retrospective group was consists of 204 patients (mean age 35.5±8.4 years) with HCV genotype 3a, who took the antiviral therapy course with pegylated interferon and ribavirin during 24 weeks. The patients were divided for two groups: 86.3% (176) had a sustained virological response (SVR),...

Background: Excessive level of cortisol in patients with Cushing’s disease (CD) can cause an immunosuppression. Therefore after resolution of hypercorticism the underline autoimmune disorders can appears.Aim: We are presenting three cases of autoimmune disorders diagnosed in patients successfully treated for CD.Results: Case 1: Woman, 37-year-old with confirmed panhypopituitarism after transsphenoidal adenomectomy (TSA) for CD...

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. We aimed to assess the differences in insulin secretion and sensitivity depending on stage of the disease and type of treatment.Design: Sixty-four patients with acromegaly (46 women; age 53 (interquartile range, IQR 47–59) years), of whom 29 were newly-diagnosed (NA group), 20 treated with somatostatin analogues (SSA group) and 15 after transsphenoïdal s...

We analyzed data of 148 patients (125 female, 23 male) with hyperprolactinemia who had been investigated in our Department during 2008–2012: Nontumor hyperprolactinemia (NT, n=46, 31%), microadenomas (MI, n=56, 38%), MAcroadenomas (MA, n=46, 31%). Patients’ age was 36 (24; 46), 37 (26; 44) and 49 (33; 60) years respectively. Men were younger than women (P=0.002). Portion of men was higher in MA than in NT and MI: 19% vs 10...

Methods: 157 patients (118 women and 39 men) aged from 30 to 73 years with radical treatment for Graves’ disease were included in this study. Patients were divided into two groups depending on a type of radical treatment: 76 patients have received radioiodine therapy, 81 persons received surgical treatment. Quality of life assessment was made by SF-36 questionnaire which includes eight scales: (physical functioning (PF), role physical functioning (RPF), pain (B), general ...

Materials and methods: 157 patients (118 women and 39 men) aged from 30 to 73 years with radical treatment for Graves’ disease were included in this study. The patients were divided into two groups depending: (76) included patients with low-normal level of TSH (0.4–2.0 mU/ml), the second group (81 patients) with upper-normal level of TSH 2.1–4.0 mU/ml. Quality of life was assessed with the help of the questionnaire Short-Form SF-36.Results...